Stereoselective Synthesis of Cyclic Guanidines by Directed Diamination of Unactivated Alkenes
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چکیده
منابع مشابه
Copper-catalyzed diamination of unactivated alkenes with hydroxylamines.
A copper-catalyzed regio- and stereoselective diamination of unactivated alkenes has been developed with O-acylhydroxylamines as electrophilic nitrogen sources and oxidants. This method provides the first example of metal-catalyzed alkene diamination for directly installing an electron-rich amino group and extends the diamination scope for the synthesis of diverse 1,2-diamines. It offers a rapi...
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This chapter offers a general review of the evolvement of methods for the stereoselective synthesis of Z-alkenes, with a focus on the development of catalytic systems towards this goal in recent years.
متن کاملHydroxyl-Directed Stereoselective Diboration of Alkenes
An alkoxide-catalyzed directed diboration of alkenyl alcohols is described. This reaction occurs in a stereoselective fashion and is demonstrated with cyclic and acyclic homoallylic and bishomoallylic alcohol substrates. After oxidation, the reaction generates 1,2-diols such that the process represents a method for the stereoselective directed dihydroxylation of alkenes.
متن کاملCopper-catalyzed diamination of unactivated alkenes with hydroxylamines† †Electronic supplementary information (ESI) available: Characterization data and experimental procedures. See DOI: 10.1039/c5sc00897b
A copper-catalyzed regioand stereoselective diamination of unactivated alkenes has been developed with O-acylhydroxylamines as electrophilic nitrogen sources and oxidants. This method provides the first example of metal-catalyzed alkene diamination for directly installing an electron-rich amino group and extends the diamination scope for the synthesis of diverse 1,2-diamines. It offers a rapid ...
متن کاملVicinal Diamination of Alkenes under Rh-Catalysis
The synthesis of 1,2-diamines has been achieved through a single-step, tandem sequence involving Rh-catalyzed aziridination followed by NaI-promoted rearrangement to an isomeric cyclic sulfamide. Facile ring opening of these products in hot water and pyridine affords differentially protected vicinal diamines. Demonstration of the utility of this method for the syntheses of (±)-enduracididine an...
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ژورنال
عنوان ژورنال: Organic Letters
سال: 2016
ISSN: 1523-7060,1523-7052
DOI: 10.1021/acs.orglett.6b02778